A stabilized aqueous Pharmaceutical composition for long-term Storage comprising etanercept and a Stabilizer to Prevent, inhibit or reduce the presence of particles in the subvisibles composition, where the Stabilizer comprises a Surfactant, and the composition is lib Re of arginine as a Stabilizer.
MANNIG MARK,MURPHY BRIAN,FARRAR DOUGLAS,HERMAN ALAN
申请号：
CL2015000051
公开号：
CL2015000051A1
申请日:
2015.01.08
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, with substantial reduction in sub-visible particles, and methods of manufacture of these compositions, methods of administration, and articles of manufacture.<；p>；LA SOLICITUD SE REFIERE A UNA COMPOSICIÓ；N FARMACÉ；UTICA ACUOSA ESTABILIZADA PARA EL ALMACENAMIENTO A LARGO PLAZO QUE COMPRENDE ETANERCEPT, UN TENSIOACTIVO, UN IÓ；N METÁ；LICO Y UN AMORTIGUADOR PARA MANTENER UN PH ENTRE 6 Y 7, PARA REDUCIR O INHIBIR LAS PARTÍ；CULAS SUBVISIBLES Y DONDE LA COMPOSICIÓ；N ESTÁ； LIBRE DE ARGININA.<；/p>；
