您的位置: 首页 > 农业专利 > 详情页

Compounds that inhibit neuronal exocytosis
专利权人:
Lubrizol Advanced Materials; Inc.
发明人:
FERRER MONTIEL, Antonio,FERNANDEZ BALLESTER, Gregorio,GARCIA ANTON, José María,CARRENO SERRAÏMA, Cristina,ALMINANA DOMENECH, Núria,DELGADO GONZALEZ, Raquel
申请号:
ES13715986
公开号:
ES2663670T3
申请日:
2013.04.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) its stereoisomers, mixtures thereof, their cosmetically or pharmaceutically acceptable salts and / or its functionally equivalent variants, characterized in that: AA1 is selected from the group consisting of -Arg-, -Gln-, -Asn-, -Glu- and -Asp-; AA2 is -Asp-; AA3 is selected from the group consisting of Ile- and -Phe-; AA4 is selected from the group consisting of -Ala- and -Asp-; AA5 is selected from the group consisting of -Arg-, -Lys-, -Gln-, -Asn- and -Glu-; AA6 is selected from the group consisting of -Met-, -MetO-, -MetO2- and -Trp-; W, X, Y, Z are amino acids and are independently selected from each other; n, m, p and q are independently selected from each other and have a value of 0 or 1; n + m + p + q is less than or equal to 2; with the proviso that if AA1 is -Gln-, AA2 is -Asp-, AA3 is -Ile-, AA5 is -Arg- and AA6 is -Trp-, then AA4 is -Ala-; R1 is selected from the group consisting of H, a polymer derived from polyethylene glycol, a substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl alkyl, substituted or unsubstituted aryl, aralkyl substituted or unsubstituted and R5-CO-, wherein R5 is selected from the group consisting of H, a substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl; R2 is selected from the group consisting of -NR3R4, -OR3 and -SR3, in which R3 and R4 are independently selected from the group consisting of H, a polymer derived from polyethylene glycol, a substituted or unsubstituted non-cyclic aliphatic group, substituted alicyclyl or unsubstituted, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylal
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充