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Neuronal exocytosis inhibitor compounds (III)
专利权人:
Lubrizol Advanced Materials; Inc.
发明人:
FERRER MONTIEL, Antonio,FERNANDEZ BALLESTER, Gregorio,GARCIA ANTON, José María,CARRENO SERRAÏMA, Cristina,ALMINANA DOMENECH, Núria,DELGADO GONZALEZ, Raquel
申请号:
ES13716774
公开号:
ES2661372T3
申请日:
2013.04.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 (I) its stereoisomers, mixtures thereof and / or its cosmetically or pharmaceutically acceptable salts, characterized in that: (i) AA1 is selected from the group consisting of -Arg-, -His-, -Lys, -Gln-, -Asn-, -Glu- and -Asp-; AA2 is selected from the group consisting of -Arg-, -His-, -Lys-, -Gln-, -Asn- and -Asp-; AA3 is selected from the group consisting of -Glu- and -Phe-; AA4 is -His-; AA5 is selected from the group consisting of -Arg-, -His-, -Lys-, -Gln- and -Asn-; AA6 is -Lys-; AA7 is selected from the group consisting of -Met-, -MetO- and -MetO2-; AA8 is -Asp-; AA9 is a link; or (ii) AA1 is selected from the group consisting of -Gln-, -Asn-, -Glu- and -Asp-; AA2 is selected from the group consisting of -Gln-, -Asn- and -Asp-; AA3 is selected from the group consisting of -Glu- and -Leu-; AA4 is -Glu-; AA5 is selected from the group consisting of -Arg-, -His-, -Lys-, -Gln- and -Asn-; AA6 is -Ile-; AA7 is selected from the group consisting of -Met-, -MetO- and -MetO2-; AA8 is -Asp-; and AA9 is selected from the group consisting of -Gln- and -Asn-; and W, X, Y, Z are amino acids and are independently selected from each other; n, m, p and q are independently selected from each other and have a value of 0 or 1; n + m + p + q is less than or equal to 2; R1 is selected from the group consisting of H, a polymer derived from polyethylene glycol, a substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl alkyl, substituted or unsubstituted aryl, aralkyl substituted or unsubstituted and R5-CO-, wherein R5 is selected from the group consisting of H, a substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and
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