ДУН Чжэн Синь (US),ПРЕРИ Николас К. (US),АФРЕТ Мария Л. (US),ЧЖАН Цзюньдун (US),РОТМАН Дебора (US),КОМСТОК Джинн Мэри (US)
申请号：
RU2012106302/10
公开号：
RU2012106302A
申请日:
2010.07.22
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. An IGF-1 analogue of formula (I) in which: A is Met, Ser or deleted； A is Gly, Ala, Asn, Asp, Gln, Glu or deleted； A is Pro, Ala, Arg, Asp, Gln, Glu , Lys or deleted； A represents Glu, Ala, Asp, Gln or deleted； A represents Thr, Ala, Asn, Asp, Gln, Glu, Ser； A represents Leu, Acc, Ala, Ile or Val； A represents Cys, D -Cys, hCys, D-hCys, β-Me-Cys, D-β-Me-Cys, N-Me-Cys, DN-Me-Cys, Ala, Pen or D-Pen； Represents Gly, Ala, Asn , Asp, Gln or Glu； Represents Ala, Arg, Asn, Asp, Gln, Glu or Lys； Represents Glu, Ala, Asp or Gln； Represents Leu, Acc, Ala, Ile or Val； Represents wallpaper Val, Ala, Ile or Leu； Represents Asp, Ala, Arg, Asn, Gln, Glu or Lys； Represents Ala, Asn, Asp, Gln, Glu, Ile, Leu or Val； Represents Leu, Acc, Ala , Ile or Val； A represents Gln, Ala, Asn, Asp or Glu； A represents Phe, Ala, Asn, Asp, Gln, Glu, Trp or Tyr； A represents Val, Ala, Ile or Leu； A represents Cys, D -Cys, hCys, D-hCys, β-Me-Cys, D-β-Me-Cys, N-Me-Cys, DN-Me-Cys, Ala, Pen or D-Pen； Represents Gly, Ala, Asn , Asp, Gln or Glu； Represents Asp, Ala, Asn, Gln or Glu； Represents Arg, Ala, Asn, Asp, Gln, Glu or Lys； Represents Gly, Ala, Asn, Asp, Gln or Glu； Represents Phe, Ala, Trp or Tyr； A represents Tyr, Ala, P he or Trp； A is Phe, Ala, Trp or Tyr； A is Asn, Ala, Asp, Gln, Glu, Ser or Thr； A is Lys, Ala, Arg, Asn, Asp, Gln, Glu or Pro； A is Pro, Ala, Arg or Lys； A is Thr, Ala, Asn, Asp, Gln, Glu or Ser； A is Gly, Ala, Asn, Asp, Gln or Glu； A is Tyr, Ala, Phe or Trp； A is Gly, Ala, Asn, Asp, Gln or Glu； Represents Ser, Ala, Thr or Val； Represents Ser, Ala, Asn, Asp, Gln, Glu or Thr； Represents Ser, Ala, Asn, Asp, Gln, Glu or Thr； A is Arg, Ala, Asn, Asp, Gln, Glu or Lys； A is Arg, Ala, Asn, Asp, Gln, Glu or Lys； A is Ala, Asn, Asp1. Аналог IGF-1 формулы (I)в которой:Aпредставляет собой Met, Ser или делетирована；Aпредставляет собой Gly, Ala, Asn, Asp, Gln, Glu или делетирована；Aпредставляет собой Pro, Ala, Arg, Asp, Gln, Glu, Lys или делетирована；Aпредставляет собой Glu, Ala, Asp, Gln
