Discloses a compound (glucagon analogue) having the formula: R1-Z-R2 wherein R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl R2 is OH or NH2 and Z is a peptide having the formula I: His-X2-X3-X4-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-X15-Ser-X17-Ala-Ala-X20-X21-Phe-Val-X24-Trp-Leu-X27-X28-Ala, X2 is Aib, Ser or Gly X3 is Gln, Gly, His, Phe, Leu, Trp, Tyr, Val, Arg, Ala, Ser, Ile, Pro, Hph, Hse, Cit, 1-Nal or 3-(heterocyclyl)alanine X4 is Gly, Ala, D-Ala, Val, Aib, Leu, D-Leu, Pro, Glu, Phe, D-Phe, Arg or Lys X15 is Asp or Glu X17 is Arg or X X20 is Arg, His or X X21 is Asp or Glu X24 is Ala or X X27 is Leu or X X28 is Arg or X wherein each residue X is independently selected from the group consisting of Glu, Lys, Ser, Cys, Dbu, Dpr and Orn further discloses the use of the compound in the manufacture of a medicament for preventing weight gain or promoting weight loss.
