Relates to peptides glucagon analogs of - Z - Formula R1 R2 where R1 is H, alkyl (c1-c4), acetyl, Benzoyl, among others R2 is Oh or NH2 Z is a Peptide made his x2 X3 X4 THR Phe - Thr - Tyr ser ASP - Be - Lys Tyr Leu x15 be x17 ala ala PHE Val X20 X21 - - - - - Trp - Leu - x27 x24 - X28 ala AIB in where it is Be or Gly X3 is GLN, glu, Gly, his, LEU, PHE, TRP, Tyr, among others x4 is Gly, ala, Val, d-ala,AIB, Leu - Leu Pro D, among others x15 is ASP or Glu x17 is ARG or arg is X X20 X21 is his, or X ASP or Glu x24 is Wing or X X is X27 Leu ARG or X28 is or X, where X is Glu, Lys, ser, CYS, dBu, DPR or Orn where the side chain of an amino acid residue is conjugated with a Substituent x l Ipofilo.This Peptide has an Amino Acid Sequence as AIB - H - H - egtftsdyskyldskaahdfvewllsa AIB - hgtftsdyskyldskaahdfvewllsa among others. It also relates to a Pharmaceutical composition that is useful in the treatment of metabolic syndrome, obesity, glucose intolerance, diabetesSE REFIERE A PEPTIDOS ANALOGOS DE GLUCAGON DE FORMULA R1-Z-R2 DONDE R1 ES H, ALQUILO(C1-C4), ACETILO, BENZOILO, ENTRE OTROS R2 ES OH O NH2 Z ES UN PEPTIDO DE FORMULA His-X2-X3-X4-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-X15-Ser-X17-Ala-Ala-X20-X21-Phe-Val-X24-Trp-Leu-X27-X28-Ala EN DONDE X2 ES Aib, Ser O Gly X3 ES Gln, Glu, Gly, His, Phe, Leu, Trp, Tyr, ENTRE OTROS X4 ES Gly, Ala, D-Ala, Val, Aib, Leu, D-Leu, Pro, ENTRE OTROS X15 ES Asp O Glu X17 ES Arg O X X20 ES Arg, His O X X21 ES Asp O Glu X24 ES Ala O X X27 ES Leu O X X28 ES Arg O X, EN DONDE X ES Glu, Lys, Ser, Cys, Dbu, Dpr O Orn EN DONDE LA CADENA LATERAL DE UN RESIDUO DE AMINOACIDO X ESTA CONJUGADO CON UN SUSTITUYENTE LIPOFILO. DICHO PEPTIDO TIENE UNA SECUENCIA DE AMINOACIDOS TAL COMO H-Aib-EGTFTSDYSKYLDSKAAHDFVEWLLSA H-Aib-HGTFTSDYSKYLDSKAAHDFVEWLLSA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE OBESIDAD, SINDROME METABOLICO, INTOLERANCIA A LA GLUCOSA, DIABETES
