MEIER, EDDI,RIBER, DITTE,DAUGAARD, JENS ROSENGREN,SKOVGAARD, MARIE
申请号：
PE0024342012
公开号：
PE03262013A1
申请日:
2011.06.23
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to analogs of glucagon - X - Z - Formula R1 R2 where R1 is H, alkyl (c1-c4), acetyl, Formilo,Among others R2 is Oh or NH2 X is a Peptide made his X2 - Gln Gly THR Phe - Thr - - - - - be ASP Tyr Lys Leu ASP Tyr - - - - - - - x16 x17 Arg - ala or ASP PHE ile Glu TRP - Leu - - - x27 X28 X29 where x2 and AIB x16 is Glu and ARG and x17 is and X20 is Lys and leu x27 is e and X28 is absent or is to be, and 29x est To absent or ala and Lys.CYS or Orn Z is absent or is a sequence 1 to 20 units of amino acids such as ala, LEU, ser, THR, Tyr, glu, CYS, Lys, ARG and Orn, dBu, DPR where the side chain of an amino acid residue and X is conjugated with a lipophilic Substituent.It also relates to a Pharmaceutical composition that is useful in the treatment of Obesity, hypertension, atherosclerosis, coronary heart diseaseSE REFIERE A ANALOGOS DE GLUCAGON DE FORMULA R1-X-Z-R2 DONDE R1 ES H, ALQUILO(C1-C4), ACETILO, FORMILO, ENTRE OTROS R2 ES OH O NH2 X ES UN PEPTIDO DE FORMULA His-X2-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-X16-X17-Arg-Ala-X20-Asp-Phe-Ile-Glu-Trp-Leu-X27-X28-X29 EN DONDE X2 ES Ser Y Aib X16 ES Glu E Y X17 ES Arg E Y X20 ES Lys E Y X27 ES Leu E Y X28 ESTA AUSENTE O ES Ser E Y X29 ESTA AUSENTE O ES Ala Y ES Lys, Cys O Orn Z ESTA AUSENTE O ES UNA SECUENCIA DE 1 A 20 UNIDADES DE AMINOACIDOS TALES COMO Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr Y Orn EN DONDE LA CADENA LATERAL DE UN RESIDUO AMINOACIDICO Y DE X ESTA CONJUGADA CON UN SUSTITUYENTE LIPOFILO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE OBESIDAD, HIPERTENSION, ATEROESCLEROSIS, CARDIOPATIA CORONARIA
