MEIER EDDI,RIBER DITTE,DAUGAARD JENS ROSENGREN,SKOVGAARD MARIE
申请号：
NZ60403311
公开号：
NZ604033A
申请日:
2011.06.23
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a compound having the formula R1-X-Z-R2 wherein R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl R2 is OH or NH2 X is a peptide which has the formula I: His-X2-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-X16-X17-Arg-Ala-X20-Asp-Phe-Ile-Glu-Trp-Leu-X27-X28-X29 (I) wherein X2 is selected from Ser and Aib X16 is selected from Glu and Y X17 is selected from Arg and Y X20 is selected from Lys and Y X27 is selected from Leu and Y X28 is selected from Ser and Y or absent X29 is Ala or absent wherein at least one of X16, X17, X20, X27 and X28 is Y wherein each residue Y is independently selected from Lys, Cys and Orn wherein the side chain of at least one amino acid residue Y of X is conjugated to a lipophilic substituent as described.
