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DÉRIVÉ POLYMÉRIQUE D'UN IMMUNOSUPPRESSEUR DE TYPE MACROLIDE
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
申请号:
EP16866237.7
公开号:
EP3378494A1
申请日:
2016.11.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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