PROBLEM TO BE SOLVED: To provide production methods of tablets which can provide sufficient tablet hardness and can easily and efficiently produce tablets having superior disintegrability even if containing a raw material having inferior disintegrability, and to provide granules for tablet raw materials which can be used suitably for producing the tablets, as well as to provide production methods thereof.SOLUTION: Disclosed are a production method of a tablet comprising injecting gas into liquid containing at least any of excipients, binders, and disintegrants to prepare a gas-containing liquid, spray-drying the gas-containing liquid to prepare granules, tableting a mixture containing the granules and a raw material having inferior disintegrability to prepare a tablet and a production method of granules of at least any of excipients, binders, and disintegrants for tablet raw materials comprising injecting gas into liquid containing at least any of excipients, binders, and disintegrants to prepare a gas-containing liquid, and spray-drying the gas-containing liquid to prepare granules and the like.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】崩壊性に劣る原料を含む場合であっても、十分な錠剤硬度を得ることができ、かつ崩壊性に優れた錠剤を簡易に効率良く製造することができる錠剤の製造方法、並びに前記錠剤の製造に好適に用いることができる錠剤原料用顆粒及びその製造方法を提供すること。【解決手段】賦形剤、結合剤、及び崩壊剤の少なくともいずれかを含む液体にガスを注入し、ガス含有液体を調製する工程と、前記ガス含有液体を噴霧乾燥し、顆粒を調製する工程と、前記顆粒と、崩壊性に劣る原料とを含む混合物を打錠し、錠剤を調製する工程とを含む錠剤の製造方法、賦形剤、結合剤、及び崩壊剤の少なくともいずれかを含む液体にガスを注入し、ガス含有液体を調製する工程と、前記ガス含有液体を噴霧乾燥し、顆粒を調製する工程とを含む錠剤原料用の賦形剤、結合剤、及び崩壊剤の少なくともいずれかの顆粒の製造方法などである。【選択図】なし
