DEANGELIS, ALAN,DEMAREST, KEITH T.,KUO, GEE-HONG,PELTON, PATRICIA,WANG, AIHUA,ZHANG, RUI
申请号：
ES05796702
公开号：
ES2546202T3
申请日:
2005.09.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I): ** Formula ** Where X is selected from a covalent bond, S, and O； And it is Y or O； Z is O or CH2, as long as Y is O, and Z is O； R1 and R2 are independently selected from H, C1-3 alkyl, C1-3 alkoxy, halo and NRaRb where Ra and Rb are independent of H or C1-3 alkyl； R3 and R4 are independently selected from H, Halo, cyano, C1-5 alkyl, hydroxy, C2-4 acyl, C1-4 alkoxy and NRcRd where Rc and Rd are independent of H or C1-3 alkyl, provided and when R3 and R4 are not both H； R5 and R6 are independently selected from H, C1-8 alkyl and substituted with C1-8 alkyl as long as R5 and R6 are not both H； R7 is selected from H, Halo, C1-8 alkyl and phenyl； R8 and R9 together form C1-9 alkylidenyl or C3-9 alkenylidenyl； or R8, R9 and the carbon atom to which they were attached together form the C3-7 cycloalkyl； n is 0, 1 or 2； and m is 0, 1 or 2； or one of its pharmaceutically acceptable salts, where "Alkyl" and "alkoxy" are optionally substituted with one or more substituents independently selected from: halogen； hydroxy； Not me； alkoxy； nitro； I rent； cyano； phenyl； heteroaryl； heterocyclyl； phenoxy； heteroaryloxy； heterocyclyloxy； thioalkyl； thiophenyl； and carboxyl； "alkenyl" is optionally substituted with one or more substituents independently selected from cyano- and thio-； and "Aryl" is optionally substituted with one or three substituents independently selected from C1-C8 alkyl； C1-C8 alkoxy； C1-C8 fluorinated alkyl； C1-C8 fluorinated alkoxy； halogen； cyano； C1-C8 alkylcarbonyl； carboxyl； hydroxy； Not me； nitro； C1-C4 alkylamino； C1-C4 dialkylamino； and mono-, di-, or substituted tri-substituted phenyl where phenyl substituents are independently selected from C1-C8 alkyl； C1-C8 alkoxy； C1-C8 fluorinated alkyl； C1-C8 fluorinated alkoxy； halogen； cyano； acetyl； carboxyl； hydroxide； amine； nitro； alkylamino； 5 or 6-membered dialkylamino and heteroaryl having one to three heteroatoms selected from N, O and S； "Heteroaryl" is optionally substitut
