COOKE, NIGEL GRAHAM,FERNANDES GOMES DOS SANTOS, PAULO,GRAVELEAU, NADEGE,HEBACH, CHRISTINA,HÖGENAUER, KLEMENS,HOLLINGWORTH, GREGORY,SMITH, ALEXANDER BAXTER,SOLDERMANN, NICOLAS,STOWASSER, FRANK,STRANG,,COOKE NIGEL GRAHAM,FERNANDES GOMES DOS SANTOS PAULO,GRAVELEAU NADEGE,HEBACH CHRISTINA,HÖGENAUER KLEMENS,HÖGENA
申请号：
ES11730637
公开号：
ES2494718T3
申请日:
2011.07.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A tetrahydro-pyrido-pyrimidine derivative of the formula (I) and / or tautomers and / or pharmaceutically acceptable N-oxides and / or salts thereof, wherein Y is selected from O or NR3； R1 is selected from phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, or -C (O) -R4 where R4 is selected from C1-C8-alkyl, halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, C1-C8-alkoxy-C1-C8-alkyl, C1-C8-alkyl-sulfonyl-C1-C8-alkyl, heterocyclyl, heterocyclyl-oxy, heterocyclyl-C1-C8-alkyl, C3-C12-cycloalkyl, C3-C12-cycloalkyl-C1-C8-alkyl, heteroaryl, heteroaryl-oxy, heteroaryl-C1-C8-alkyl, hydroxy, C1- C8-alkoxy, amino, N-C1-C8-alkylamino or N, N-di-C1-C8-alkyl-amino, wherein "C1-C8-alkyl" in N-C1-C8-alkyl-amino and N, N-di-C1-C8-alkyl-amino may be unsubstituted or substituted by halogen, hydroxy or C1-C4-alkoxy； wherein "C3-C12-cycloalkyl" in C3-C12-cycloalkyl and C3-C12-cycloalkyl-C1-C8-alkyl may be unsubstituted or substituted by 1-5 substituents independently selected from oxo, halogen, C1-C8-alkyl , halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, hydroxyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N-C1-C8-alkyl-amino, N , Ndi- C1-C8-alkyl-amino, C1-C8-alkyl-carbonyl, halo-C1-C8-alkyl-carbonyl, hydroxy-C1-C8-alkyl-carbonyl or C1-C8-alkoxy-C1-C8-alkyl -carbonyl； wherein the "heterocyclyl" is selected from oxyranyl, aziridinyl, oxetanyl, thienyl, azetidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, 2,3-dihydrofuranyl, 2,5-dihydrofuranyl, 2,3-dihydrothiophenyl, 1-pyrrolinyl, 2- pyrrolinyl , 3-pyrrolinyl, tetrahydropyranyl, piperidinyl, tetrahydrothiopyranyl, morpholinyl, thiomorpholinyl, piperazinyl, azepanyl, tiepanyl or oxepanyl； each of which is unsubstituted or substituted by 1-5 substituents independently selected from oxo, halogen, C1-C8-alkyl, halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, hydroxyl, C1-C8- alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N-C1-C8-alkyl-amino, N, N-di-C1-C8-alkyl-amino, C1-C8-alkyl-carbonyl, halo- C1-C8-al
