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Azabicyclo [3.1.0] hexyl derivatives as dopamine D3 receptor modulators
- 专利权人:
- CAPSUGEL BELGIUM NV;GLAXO GROUP LIMITED
- 发明人:
- BERTANI, BARBARA,CARDULLO, FRANCESCA,DAMBRUOSO, PAOLO,MARZORATI, PAOLA,MICHELI, FABRIZIO,PASQUARELLO, ALESSANDRA,SERI, CATIA,TEDESCO, GIOVANNA
- 申请号：
- ES08834746
- 公开号：
- ES2469945T3
- 申请日:
- 2008.10.01
- 申请国别(地区):
- ES
- 年份:
- 2014
- 代理人:
- 摘要：
- A compound of formula (I) 'or a salt thereof: in which the bold highlighting of the bonds means the "cis" configuration, and in which R1 is a 5-membered heteroaryl group, optionally condensed with a hetero or 6-member carbocycle； said 5 or 11 member system may be optionally substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1- alkanoyl 4, C1-4 haloalkoxy and SF5； and n is 1 or 2； with the proviso that the compound of formula (I) 'is not: 5- (2-thienyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl} propyl) -2.4 (1H, 3H) -pyrimidinedione； 5- (2-Thienyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl} propyl) hydrochloride - 2,4 (1H, 3H) -pyrimidinedione； 5- (3-methyl-2-thienyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl} propyl ) -2.4 (1H, 3H) -pyrimidinedione； 5- (3-methyl-2-thienyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl hydrochloride } propyl) -2.4 (1H, 3H) -pyrimidinedione； 5- (3-methyl-2-thienyl) -1- (4 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl} butyl ) -2.4 (1H, 3H) -pyrimidinedione； 5- (3-methyl-2-thienyl) -1- (4 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl hydrochloride } butyl) -2.4 (1H, 3H) -pyrimidinedione； 5- (3,5-dimethyl-4-isoxazolyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3-yl } propyl) -2.4 (1H, 3H) -pyrimidinedione； 5- (3,5-Dimethyl-4-isoxazolyl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0] hex-3 hydrochloride -yl} propyl) 25 -2.4 (1H, 3H) -pyrimidinedione； 5- (2,4-dimethyl-1,3-oxazol-5-yl) -1- (3 - {(1S, 5R) -1- [4- (trifluoromethyl) phenyl] -3-azabicyclo [3.1.0 ] hex-3-yl} propyl) -2.4 (1H, 3H) -pyrimidinedione； 5- (2,4-Dimethyl-1,3-oxazol-5-yl) -1- (3 - {(1S, 5R) -1-
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
