FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
Giovanni Bottegoni,Alessio De Simone,Gian Filippo Ruda,Andrea Cavalli,Tiziano Bandiera,Daniele Piomelli
申请号：
US14905727
公开号：
US09828352B2
申请日:
2014.07.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereofwherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
