Wilfried Braje;Andreas Haupt;Wilfried Lubisch;Roland Grandel;Karla Drescher;Herve Geneste;Liliane Unger;Daryl R. Sauer
发明人:
Wilfried Braje,Andreas Haupt,Wilfried Lubisch,Roland Grandel,Karla Drescher,Herve Geneste,Liliane Unger,Daryl R. Sauer
申请号：
US10583590
公开号：
US08207160B2
申请日:
2004.12.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to tetrahydrobenzazepines of the general formula Iin which the variables Ar, A, B, Y, R1 and R2 have the meanings indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid addition salts of these compounds and the physiologically tolerated acid addition salts of the N-oxides.The invention also relates to a pharmaceutical composition that comprises at least one tetrahydrobenzazepine compound of the formula I, the physically tolerated acid addition salt of I, the N-oxide of compound of the formula I and/or the physically tolerated acid addition salts of the N-oxides of I, and further to the use of a compound according to the present invention for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists. The compounds according to the invention are preferably useful for the treatment of disorders of the central nervous system such as schizophrenia and depression and for the treatment of renal function disorders.
