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Tetrahydrobenzazepine and their use in modulating dopamine D3 receptors
专利权人:
アボット ゲーエムベーハー ウント カンパニー カーゲー
发明人:
ブラーイエ,ビルフリート,ハオプト,アンドレアス,ルビツシユ,ビルフリート,グランデール,ローラント,ドレツシヤー,カルラ,ジユネスト,エルベ,アンガー,リリアーヌ,サウアー,ダリル・アール,ブラーイエ,ビルフリート,ハオプト,アンドレアス,ルビツシユ,ビルフリート,グランデール,ローラント,ドレツシヤー,カルラ,ジユネスト,エルベ,アンガー,リリアーヌ,サウアー,ダリル・アール
申请号:
JP2006544363
公开号:
JP4982184B2
申请日:
2004.12.17
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
The invention relates to tetrahydrobenzazepines of the general formula I in which the variables Ar, A, B, Y, R1 and R2 have the meanings indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid addition salts of these compounds and the physiologically tolerated acid addition salts of the N-oxides. The invention also relates to a pharmaceutical composition that comprises at least one tetrahydrobenzazepine compound of the formula I, the physically tolerated acid addition salt of I, the N-oxide of compound of the formula I and/or the physically tolerated acid addition salts of the N-oxides of I, and further to the use of a compound according to the present invention for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists. The compounds according to the invention are preferably useful for the treatment of disorders of the central nervous system such as schizophrenia and depression and for the treatment of renal function disorders.
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中国工程科技知识中心
来源网址:
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