Mark R. Nicolls,Xinguo Jiang,Geoffrey C. Gurtner,Gregg L. Semenza,Jayakumar Rajadas
申请号：
US14653245
公开号：
US09763899B2
申请日:
2013.12.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. is topically applied to the surface of tissues during episodes of graft rejection.
