INJECTABLE ANTIOXIDANT FORMULATION FOR INTRAVENOUS USE OF SODIUM ASCORBATE IN HIGH DOSAGE, N-ACETYL CYSTEINE, AND DEFEROXAMINE METHOD OF ADMINISTRATION AND USE FOR PREVENTING INJURY DUE TO REPERFUSION AND KIT
Ramón RODRIGO SALINAS,Gina SÁNCHEZ VERGARA,Juan Carlos PRIETO DOMINGUEZ,Rubén AGUAYO NAYLE,Fernando FLORENZANO URZUA,Juan Guillermo GORMAZ ARAYA
申请号：
US15532556
公开号：
US20170333393A1
申请日:
2015.12.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention refers to an injectable antioxidant formulation for intravenous use comprising sodium ascorbate in high dosage as a first antioxidant agent, N-acetyl cysteine as a second oxidant agent and deferoxamine as an iron chelating agent, plus pharmaceutically acceptable excipients. And an administration method of said formulation that results in a synergic and improved effect to prevent injury due to reperfusion in an organ. In particular, to prevent injury due to early and late reperfusion in patients diagnosed with acute myocardium infarction and indication of primary coronary angioplasty. The invention further refers to the use of the formulation to prevent injury due to reperfusion in patients with acute myocardium infarction, subjected to primary coronary angioplasty.
