СМИТ Третий Джордж Джозеф (US),УИЛЛС Кеннет Нельсон (US),ЧЖУ Джефф Сяньчао (US)
申请号：
RU2012102701/10
公开号：
RU2012102701A
申请日:
2010.07.20
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. An immunogen containing an antigenic tau peptide linked to an immunogenic carrier, wherein said antigenic tau peptide contains an amino acid sequence selected from SEQ ID NO: 4, 6-26, 105 and 108-112, and where said antigenic tau peptide covalently linked to the specified immunogenic carrier via a linker represented by the formula (G) C, where the specified linker is either at the C-end (peptide (G) C) or at the N-end of the (C (G) -peptide) of the specified peptide, and where n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.2. The immunogen according to claim 1, where the specified antigenic tau peptide contains an amino acid sequence selected from SEQ ID NO: 4 and 6-13.3. The immunogen according to claim 2, wherein said antigenic tau peptide consists of the amino acid sequence shown in SEQ ID NO: 11.4. The immunogen according to claim 1, where the specified antigenic tau peptide contains an amino acid sequence selected from SEQ ID NO: 14-19.5. The immunogen according to claim 4, where the specified antigenic tau peptide consists of the amino acid sequence shown in SEQ ID NO: 16.6. The immunogen according to claim 1, where the specified antigenic tau peptide contains an amino acid sequence selected from SEQ ID NO: 20-24.7. The immunogen of claim 6, wherein said antigenic tau peptide consists of the amino acid sequence shown in SEQ ID NO: 21.8. The immunogen according to claim 1, where the specified antigenic tau peptide contains an amino acid sequence selected from SEQ ID NO: 105 and 108-112.9. The immunogen of claim 8, where the specified antigenic tau peptide consists of the amino acid sequence shown in SEQ ID NO: 105.10. An immunogen according to any one of claims 1 to 9, wherein said immunogenic carrier is a virus-like particle selected from the group consisting of HBcAg VLP, HBsA1. Иммуноген, содержащий антигенный тау-пептид, связанный с иммуногенным носителем, где указанный антигенный тау-пептид содержит аминокислотную последовательность, выбранную из SEQ ID NO:4,
