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HOMODIMERIC PROTEIN STRUCTURES
专利权人:
ВЭКСИБОДИ АС (NO)
发明人:
РУФФИНИ Пьер Адельки (IT),БОГЕН Бьярне (NO),ФРЕДРИКСЕН Агнете Брунсвик (NO)
申请号:
RU2013103335/10
公开号:
RU2013103335A
申请日:
2011.06.24
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A homodimeric protein of two identical amino acid chains, where each amino acid chain contains a targeting group containing an amino acid sequence having at least 80% sequence identity 5-70 from SEQ ID NO: 1, and an antigenic group, where the targeting group and antigenic group connected through a motif for dimerization. 2. The homodimeric protein of claim 1, wherein said targeting group contains amino acids 3-70 of SEQ ID NO: 1.3. The homodimeric protein of claim 1, wherein said targeting group consists of amino acids 5-70 of SEQ ID NO: 1.4. The homodimeric protein of claim 1, wherein said targeting group consists of amino acids 3-70 from SEQ ID NO: 1.5. The homodimeric protein of claim 1, wherein said targeting group consists of amino acids 1-70 from SEQ ID NO: 1.6. The homodimeric protein of claim 1, wherein the antigenic group is antigenic scFv. 7. The homodimeric protein of claim 1, wherein the linker, such as a linker (GS), connects V and V in antigenic scFv. The homodimeric protein of claim 1, wherein the antigenic scFv is derived from monoclonal Ig produced by myeloma or lymphoma cells. The homodimeric protein of claim 1, wherein the antigenic group is telomerase or a functional part thereof. The homodimeric protein of claim 9, wherein said telomerase is hTERT. 11. A homodimeric protein according to claim 1, wherein the antigenic group originates from a bacterium. A homodimeric protein according to claim 11, wherein the antigenic group derived from the bacterium is selected from the tuberculosis antigen and the brucellosis antigen. A homodimeric protein according to claim 1, wherein the antigenic group originates from the virus. A homodimeric protein according to claim 13, wherein the antigenic group derived from the virus originates from HIV. The homodimeric protein of claim 14, wherein1. Гомодимерный белок из двух идентичных аминокислотных цепей, где каждая аминокислотная цепь содержит нацеливающую группу, содержащую аминокислотную последовательность, о
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