The bright Ti Gong mono- Seed of this Hair is with HSP90 inhibiting effect and with the novel bis- Ring formula compound of cancer Fine born of the same parents proliferation inhibiting effect. The following general formula (I) compound represented Qi Which of Huo,In formula,X1,X2,X3 and X4 at least 1 Ge is N or N oxide,It is other identical or different,Indicate C-R2； Y1,Y2,Y3 and Y4 any 1 Ge or 2 Ge is C-R4,It is other same or different,Indicate CH or N； R1 expression can have substituent group and have 1~4 Ge Election from N,The not Eat He Miscellaneous Ring base of S and O Zhong Miscellaneous atom Single Ring Huo bis- Ring； R2 expression Hydrogen atom,It can have the alkyl etc. of the carbon atom Number 1~6 of substituent group； R3 expression-CO-R5 etc.； R4 expression Hydrogen atom,- N(R7) (R8) etc.； R5 Biao Shi Hydroxyalkyl base,Amino etc.； R7 and R8 are identical or different,Expression Hydrogen atom,It can have the alkyl etc. of the carbon atom Number 1~6 of substituent group.本發明提供一種具有HSP90抑制作用、且具有癌細胞增殖抑制效果的新型的二環式化合物。下述通式（I）所示的化合物或其鹽，式中，X1、X2、X3和X4至少1個爲N或N氧化物，其他的相同或不同，表示C－R2；Y1、Y2、Y3和Y4任意1個或2個爲C－R4，其他相同或不同，表示CH或N；R1表示可以具有取代基且具有1～4個選自N、S和O中的雜原子的單環性或二環性的不飽和雜環基；R2表示氫原子、可以具有取代基的碳原子數1～6的烷基等；R3表示－CO－R5等；R4表示氫原子、－N（R7）（R8）等；R5表示羥基、氨基等；R7和R8相同或不同，表示氫原子、可以具有取代基的碳原子數1～6的烷基等。
