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PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS
专利权人:
GIULIANI INTERNATIONAL LIMITED
发明人:
SERGIO BARONI,PIERRE DESREUMAUX,SALVATORE BELLINVIA
申请号:
HRP20120473
公开号:
HRP20120473T1
申请日:
2012.06.05
申请国别(地区):
HR
年份:
2012
代理人:
摘要:
Rosiglitazone, 5-ASA or structurally analagous compounds according to the general formula (1): <;FORMULA>; in which R1 and R2 which maybe identical or different, are selected from the group comprising -H or a linear or branched alkyl group having from 1 to 6 carbon atoms or tegether form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising -H, -OH, -COOH, in which R3 is selected from H, phenyl, benzyl, -CF3 or -CF2CF3, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms; or compounds or according to the general formula (Ia); <;FORMULA>; in which R1 and R2, which may be identical or defferent, are selected from the group comprising H, -CnH2n-1, where n= 1-6, a linear or branched aldyl group having from 1 to 6 carbon atoms, or together form an aromatic or apiphatic ring with 5 or 6 atoms; R3 is selected from -CO-CH, -NHOH, -OH, -OR6 in which R6 is a linear or branched alkyl group having from 1 to 6 carbon atoms; R3 is selected from -CO-CH, -NHOH, -OH, -OR6 in which R6 is a linear or branched alkyl group having from 1 to 6 carbon atoms; R4 is selected from H, a linear or branched alkyl group having from 1 to 6 carbon atoms, phenyl, benxyl, -CF3 or -CF2CF3 vinyl or allyl; R5, R7, R8 are hydrogen atoms; or R3 and R4, R4 and R5, or R7 and R8 together form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O; in the induction of CAMP expression in the gut.Spoj izabran između metoksi aminofenil propionske kiseline amino N hidroksi metoksibenzamida etoksi aminofenil propionske kiseline ili etoksi aminofenil propionske kiseline za uporabu u liječenju i ili prevenciji akutnog divertikulitisa Patent sadrži još patentna zahtjeva
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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