CARBAMOYLOXYARYL ALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUND AND METHOD OF TREATING PAIN, ANXIETY AND DEPRESSION
KVAK B'ong Sung (KR),КВАК Бьонг Сунг (KR),MUN Khong Sik (KR),МУН Хонг Сик (KR),I Khan-Dzhu (KR),И Хан-Джу (KR),KANG Jong Sun (KR),КАНГ Йонг Сун (KR),IM Deh Dzhung (KR),ИМ Дэ Джунг (KR),ChEh Jun Khi (K,KVAK BONG SUNG,MUN KHONG SIK,I KHAN-DZHU,KANG JONG SUN,IM DEH DZHUNG,CHEH JUN KHI,ЧЭ Юн Хи (KR),CHEH SANG MI,Ч
申请号：
RU2009146132/04
公开号：
RU0002460731C2
申请日:
2008.04.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: in general formula 1 , a cyclic ring can be selectively formed； each of R1 and R2 is independently selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms and phenetyl or R1 and R2 together form a 5- or 6-member heterocyclic ring or R1 and R2 together with Ar1 form a bicyclic ring； Ar1 is selected from a group consisting of furanyl, thionyl, methylene dioxyphenyl and phenyl, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms, a halogen such as F, O and Br, with a straight or branched alkoxy chain, having 1-6 carbon atoms, nitro and trifluoromethyl； Z is hydrogen or fluorine, or taken together with Ar1 forms a bicyclic ring； Ar2 is selected from a group consisting of phenyl, methylene dioxyphenyl, pyridine pyrimidine, naphthyl, bis(fluorophenyl)methyl and quinoxaline, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain, having 1-6 carbon atoms, hydroxy, halogen, with a straight or branched alkoxy chain having 1-6 carbon atoms, nitro, acetyl, tert-butyl acetate, trifluoromethyl, amino and acetate； n is equal to 1 or 2； m is an integer from 0 to 2.EFFECT: improved method.26 cl, 2 dwg, 2 tbl, 87 exИзобретение относится к производным общей формулы 1, их фармацевтически приемлемым солям или гидратам, фармацевтическим композициям на их основе и способу лечения боли, беспокойства или депрессии. В общей формуле 1:может селективно образовывать циклическое кольцо； R1 и R2 каждый независимо выбирают из группы, состоящей из водорода, с прямой или разветвленной цепью алкила, имеющего от 1 до 6 атомов углерода и фенэтила или R1 и R2, взятые вместе, образуют 5-членное или 6-членное гетероциклическое кольцо или R1 и R2, взятые вместе с Ar1, образуют бицик
