An antibody-drug conjugate having a structure represented by formula (I)wherein m is 1, 2, 3, or 4 and Ab is an anti-glypican-3 antibody having heavy and light chain CDRs as disclosed herein.本發明提供一種抗體藥物結合物,其具有由式(I)表示之結構:其中m為1、2、3或4,且Ab為具有如本文所揭示之重鏈及輕鏈CDRs的抗磷脂醯肌醇蛋白聚糖-3抗體。