Disclosed herein are glycan-modified anti-CD4 monoclonal antibodies with N-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for HIV prevention and therapy are also disclosed.本發明係揭示具有N-連結醣類連接至可變區之醣修飾抗CD4單株抗體。本發明亦揭示用於生產此類抗體之表現載體及細胞株,以及此類抗體於HIV預防及治療之用途。