PROMIS NEUROSCIENCES INC.;THE UNIVERSITY OF BRITISH COLUMBIA
发明人:
CASHMAN, NEIL R.,PLOTKIN, STEVEN S.,KAPLAN, JOHANNE,SILVERMAN, JUDITH MAXWELL,GIBBS, EBRIMA
申请号：
CA3070085
公开号：
CA3070085A1
申请日:
2018.07.18
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The disclosure pertains to antibodies that bind A-beta oligomers and methods of making and using said antibodies. Also provided are chimeric or humanized antibodies, including antibodies having CDRs in Table 2 and/or having a sequence as set forth in Table 4B or a sequence with at least 50% sequence identity thereto optionally wherein the CDR amino acid sequences are as set for forth in SEQ ID Nos: 74-79. Also provided are methods and uses thereof as well as kits comprising said antibodies.
