Use of inhibitors to treat, for example, cardiovascular conditions.Claim 1: a compound having the formula (1) or a Salt or prodrug of this Pharmaceutical acceptable from the point of view, where r u00b9 is a Aromatic Ring of 5 to 6 members that is optionally 1 to 3 heteroatoms selected irrespective of Nitrogen, Sulfur Or a bicyclic ring and Oxygen, which consists of two FUSED Rings of 5 to 6 members,Partially or fully saturated, fully saturated unsaturated, considered independently, which are optionally 1 to 4 heteroatoms selected irrespective of Nitrogen, sulfur, and Oxygen； and optionally r u00b9 is mono -, di - or trisustituido independently Halo, cyano, amino, hydroxyl, alkyl c u2081 u208b u2084, c u2081 u208b u2084 alkoxy alkyl, alkoxy c u2081 u208b u2084 c u2081 u208b u2084,Hydroxy alkoxy c u2082 u208b u2084 c u2081 u208b u2084 carbamoyl -, alkoxy, amino alkoxy c u2082 u208b u2084 c u2081 u208b u2084 alkyl, cyano -, mono - or di - N - n, N - alkyl c u2081 u208b u2084amino, aminocarbonilo, mono - or di - N - n, N - alkyl c u2081 u208b u2084aminocarbonilo, Alquiltio c u2081 u208b u2084, aminosulfonilo, c u2081 u208b u2084sulfinilo alkyl, alkyl c u2081 u208b u2084su Lfonilo or mono - or di - N - n, N - alkyl c u2081 u208b u2084aminosulfonilo, where anyone c u2081 u208b u2084 alkyl or alkoxy c u2081 u208b u2084 can optionally be mono -,Di - or potency of the Tri substituted compounds with Fluorine； or where r u00b9 is optionally substituted with an Aromatic Ring of 5 to 6 members that is optionally 1 to 3 heteroatoms selected irrespective of Nitrogen, sulfur, and Oxygen； R u00b2 is a linear carbon chain of 1 to 14 members fully Partially or fully unsaturated saturated, unsaturated, where carbonExcept for the carbon may be branched Connector, a), (b) can be replaced optionally one or two heteroatoms selected irrespective of Oxygen, Sulfur and Nitrogen, where Sulphur is optionally or mono alkylated with OXO, c) can be Optionally, mono -, di - or Potency of the Tri s
