CASTANEDO GEORGETTE,CHAN BRYAN,GOLDSTEIN DAVID MICHAEL,KONDRU RAMA K,LUCAS MATTHEW C,PALMER WYLIE SOLANG,PRICE STEPHEN,SAFINA BRIAN,SAVY PASCAL PIERRE ALEXANDRE,SEWARD EILEEN MARY,SUTHERLIN DANIEL P,S
申请号:
IN7863/DELNP/2011
公开号:
IN2011DN07863A
申请日:
2011.10.12
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
Formula I (la and lb) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.