Irina S. Chuckowree;Bing-Yan Zhu;Alan G. Olivero;Nan Chi Wan;Jennafer Dotson;Daniel P. Sutherlin;Timothy Heffron;Steven Staben;Shumei Wang;Adrian J. Folkes
发明人:
Jennafer Dotson,Timothy Heffron,Alan G. Olivero,Daniel P. Sutherlin,Steven Staben,Shumei Wang,Bing-Yan Zhu,Irina S. Chuckowree,Adrian J. Folkes,Nan Chi Wan
申请号：
US13129091
公开号：
US20120035208A1
申请日:
2009.11.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of Formula (I), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer or inflammation mediated by lipid kinases. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
