Georgette Castanedo,Irina Chuckowree,Adrian Folkes,Daniel P. Sutherlin,Nan Chi Wan
申请号：
US12474613
公开号：
US08158624B2
申请日:
2009.05.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
