Melissa Egbertson;Anthony J. Roecker;Xuanjia Peng;Merck Sharp & Dohme Corp.;Kristen L. G. Jones;Xiu Wang;Dansu Li;Mark E. Layton
发明人:
Mark E. Layton,Anthony J. Roecker,Melissa Egbertson,Kristen L. G. Jones,Dansu Li,Xiu Wang,Xuanjia Peng
申请号：
US15038805
公开号：
US09586968B2
申请日:
2014.11.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
