HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

GRESHOCK, Thomas,MULHEARN, James,ZHENG, Junying,KIM, Ronald,ZHANG, Ting,ROECKER, Anthony,WON, Walter,NANTERMET, Philippe,ANAND, Rajan,ZHOU, Gang,WANG, Deping,GUO, Liangqin

申请号：

SG11201804936U

公开号：

SG11201804936UA

申请日:

2016.12.14

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

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中国工程科技知识中心

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http://www.ckcest.cn/home/