N V SATHEESH MADHAV,MR ABHIJEET OJHA,MS VISHAKHA JAISWAL
申请号：
IN3578/DEL/2015
公开号：
IN2015DE03578A
申请日:
2015.11.03
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The current invention explores a process for isolating a novel bio-polymer from the pulp of Trichosanthes Cucumerina and its in-built properties for pharmaceutical application. The biopolymer was isolated from the fruit pulp of the Trichosanthes Cucumerina by adding non solvent to the aqueous extract of the fruit pulp and subjected for refrigeration to recover the biopolymer. The physicochemical characters and spectral behaviour was determined by performing the IR, NMR and DSC studies and was devoid of cell line toxicity in human neuroblastoma cell line. The biopolymer showed presence of carboxylic, amino and hydroxy] groups in FTIR spectra. The inbuilt properties of the biopolymer was screened by designing API loaded flexy films and subjected for performance evaluation. The results revealed that biopolymer showed inbuilt filmability and mucoadhesivity due to the presence of carboxylic as well as amino group. This novel biopolymer can be used as a bio- functional excipient for designing drug loaded films as well as mucoadhesive films.
