HOLDER, Jerry Ryan,SWAMINATH, Gayathri,FROHN, Michael J.,LANMAN, Brian Alan,REED, Anthony B.,MIRANDA, Leslie P.,ALLEN, John Gordon,PICKRELL, Alexander J.,SIEGMUND, Aaron C.,PENNINGTON, Lewis D,YANG, B
申请号：
EP19211432
公开号：
EP3674314A2
申请日:
2015.06.10
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
