Holder, Jerry Ryan,Swaminath, Gayathri,Frohn, Michael J.,Lanman, Brian Alan,Reed, Anthony B.,Miranda, Leslie P.,Allen, John Gordon,Pickrell, Alexander J.,Siegmund, Aaron C.,Pennington, Lewis D.,Yang,
申请号：
AU2015274574
公开号：
AU2015274574A1
申请日:
2015.06.10
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
