Jerry Ryan HOLDER,Gayathri SWAMINATH,Michael J. FROHN,Brian Alan LANMAN,Anthony B. REED,Leslie P. Miranda,John G. Allen,Alexander J. Pickrell,Aaron C. Siegmund,Lewis D. Pennington,Bryant Yang
申请号：
US15317911
公开号：
US20170107255A1
申请日:
2015.06.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
