HOLDER, JERRY RYAN,SWAMINATH, GAYATHRI,FROHN, MICHAEL J.,LANMAN, BRIAN ALAN,REED, ANTHONY B.,MIRANDA, LESLIE P.,ALLEN, JOHN GORDON,PICKRELL, ALEXANDER J.,SIEGMUND, AARON C.,PENNINGTON, LEWIS D.,YANG,
申请号：
CA2951391
公开号：
CA2951391A1
申请日:
2015.06.10
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
