A use of a tetrahydroindole derivative according to Formula (I): ** Formula ** wherein G1 is selected from the following groups: ** Formula ** G2 is selected from optionally substituted alkyl, optionally substituted aryl optionally, optionally substituted heteroaryl, optionally substituted C3-C8-cycloalkyl and optionally substituted heterocycloalkyl； G3 is -C (O) NR13R14； A1, A2, A3 and A4 are independently selected from CR10 or N； B1, B2 and B3 are independently selected from NR11, O, CR11R12 and S； D1 and D2 are CR11； R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from H, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl optionally, optionally substituted heteroaryl, optionally substituted C3-C8-cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted heteroalkyl, OH； NH2, NHR15, NHCOR15, NHSO2R15, SR15, S (O) R15, SO2R15, CO2H and CONHR15； R10 is selected from H； halogen, OH, O-alkyl, NH-Alkyl, N (Alkyl) 2 and optionally substituted alkyl； R11 and R12 may be independently absent or when present they are selected from H； halogen, optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl； R13 is selected from optionally substituted amino alkyl and optionally substituted heterocycloalkyl alkyl； R14 is independently selected from H and optionally substituted alkyl； R15 is selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-C8-cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl optionally, optionally substituted alkyl aryl, optionally substituted alkyl heteroaryl, optionally substituted aryl alkyl, optionally substituted heteroaryl, optionally substituted C3-C8-alkyl alkyl, optionally substituted heterocycloalkyl alkyl, C3- C8-optionally substituted alkylcycloalkyl and
