Patrick J. Pagano,Peter Wipf,Maria E. Cifuentes-Pagano,Erin M. Skoda
申请号：
US14888390
公开号：
US09796681B2
申请日:
2014.05.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof:wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl Ra is hydrogen, —CH2R2, R3, or —SO2R4 R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl R4 is lower aliphatic, or substituted or unsubstituted aryl and R5 is hydrogen, halogen, or lower aliphatic.
