FIELD: chemistry.SUBSTANCE: invention relates to pyrazoline dione derivative of formula,as well as to its pharmaceutically acceptable salt, where R1 is selected from hydrogen； possibly substituted C1-C6alkyl； possibly substituted phenyl； possibly substituted C1-C6alkylphenyl； possibly substituted phenylC1-C6alkyl； possibly substituted pyridyl； possibly substituted C1-C6alkylpyridyl； and possibly substituted pyridylC1-C6alkyl； R2 is hydrogen； R3 is hydrogen； R4, R5, R6 and R7 are hydrogen； R8, R9, R10 and R11 are independently selected from hydrogen atoms and C1-C6alkyls； R12 is selected from hydrogen； -CHR17R18； possibly substituted C1-C6alkoxy-carbonyl, possibly substituted -C(O)-phenyl； possibly substituted C1-C6alkylphenyl； possibly substituted phenylC1-C6alkyl, possibly substituted C1-C6alkylheteroaryl or possibly substituted heteroarylC1-C6alkyl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl； R17 and R18 are independently selected from hydrogen； possibly substituted phenyl； possibly substituted heteroaryl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl； X is selected from O, NR12, S and S(O)2； n is integer number, selected from 0 and 1； with term "substituted" meaning that said group is substituted with 1-5 substituents, selected from "C1-C6alkyl", "C1-C6alkoxy" and "halogens". Invention also relates to pharmaceutical composition, based on formula (I) compound, intermediate compound of formula,method of obtaining formula (I) and (II) compounds.EFFECT: novel pyrazoline dione derivatives, useful for inhibition of activity or function of
