University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Patrick Joseph Pagano,Peter Wipf,Maria Eugenia Cifuentes-Pagano,Erin M. Skoda
申请号：
US16444824
公开号：
US20200140387A1
申请日:
2019.06.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof:wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl； Ra is hydrogen, —；CH2R2, R3, or —；SO2R4； R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl； R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl； R4 is lower aliphatic, or substituted or unsubstituted aryl； and R5 is hydrogen, halogen, or lower aliphatic.
