CHAN, Ho Man,GU, Xiang-Ju Justin,HUANG, Ying,LI, Ling,MI, Yuan,QI, Wei,SENDZIK, Martin,SUN, Yongfeng,WANG, Long,YU, Zhengtian,ZHANG, Hailong,ZHANG, Ji Yue (jeff),ZHANG, Man,ZHANG, Qiong,ZHAO, Kehao
申请号：
PE0011542017
公开号：
PE13072017A1
申请日:
2015.12.21
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Triazolopyrimidine derivatives relates to compounds of formula (i) where ----- is a link or a double Bond R1 and R2 are H is Halogen or Halogen R3, R4 phenyl is H, among othersC1-c4 alkyl or Halogen R5 is Oh or c1-c4 alkyl n is 0 OR 1.Preferred compounds are: 8 (- 1.3 - 1H pyrazole - dimethyl - 5 - (IL) - N - (5 - fluoro - 2.3 - dihidrobenzofuran - 4 - yl) methyl) - [1,2,4] triazolo [4,3] - 5 - (pyrimidin-2-yl Amine n - (5 - fluoro - 2Dihidrobenzofuran - 3 - 4 - yl) methyl) - 4 - (2 - metilpiridin - 3 - yl) - [1,2,4] triazolo [4,3] - 5 - (pyrimidin-2-yl Amine among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of the repressive complex Polynomial 2 (PRC2) being useful in the treatment of lymphomas, tumor and cancerSE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRIMIDINA DE FORMULA (I) DONDE ----- ES UN ENLACE SIMPLE O UN ENLACE DOBLE R1 Y R2 SON H O HALOGENO R3 ES HALOGENO, FENILO, ENTRE OTROS R4 ES H, HALOGENO O ALQUILO C1-C4 R5 ES OH O ALQUILO C1-C4 n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 8-(1,3-DIMETIL-1H-PIRAZOL-5-IL)-N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-8-(2-METILPIRIDIN-3-IL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL COMPLEJO REPRESIVO DEL POLINOMIO 2 (PRC2) SIENDO UTILES EN EL TRATAMIENTO DE LINFOMAS, TUMORES Y CANCER
