CHARIFSON, PAUL,CLARK, MICHAEL P.,BANDARAGE, UPUL K.,BETHIEL, RANDY S.,COURT, JOHN J.,DENG, HONGO,DRUTU, IONA,DUFFY, JOHN P.,FARMER, LUC,GAO, HUAI,GU, WEXIN,JACOBS, DYLAN H.,KENNEDY, JOSEPH M.,LEDEBOE
申请号：
PE0021202011
公开号：
PE05082012A1
申请日:
2010.06.17
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a pirrolopiridina Derivative of formula (IA), where Z1 IS F, CL, CN, NO2, among others Z2 is R *, or * *, CO2R, among others Z3 is H, Oh, NH2, halogen, among others r1 is H or c1-c6 alkyl R2 is H, F, NH2, NH (c1-c4 alkyl), among others R3 is H, CL, F, Oh, o (c1-c4 alkyl), among others R4 is (a)(b) or (c) t is not an carbociclo C3 - C10 Aromatic optionally replaced with a non Aromatic heterocycle ja or 3 to 10 members optionally replaced with JB J is a non Aromatic heterocycle 3 to 10 members optionally replaced with JB d is a non Aromatic heterocycle of 4 to 10 Member S optionally replaced with JDL ja and JB are Halogen, CN, NCO, among others R9 is H, halogen,Oh, CN, C1 - C6 amino alkyl R IS h, alkyl of C1 - C6, C8 Aromatic carbociclo C3 - No, among others JDL is Halogen, CN, Oxo, among others R13 and R14 are h, halogen, alkyl of C1 - C6 J Z, among others and are 1 or 2 t is 0, 1 or 2.Preferred compounds are: acid (R) - 3 - (3 - ((2 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridin-3-yl) - 5 - fluoropirimidin - 4 - piperidine ilamino) methyl) - 1 - carboxylic acid pyrazine carbonyl) - 2 - (S) - 1 - (3 - ((2 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridin-3-yl) - 5 - fluoropirimidin - 4 - ilamino) methyl) piperidin-1-yl) - 2 - metoxietanona, (S) - 1 - (3 - ((2 - (5 - Chloro - 1H pyrrolo [2,3 - B] pyridin-3-yl) - 5 - methyl - 4 - ilamino) fluoropirimidin) piperidin-1-yl) propan-1-one, among others. It also relates to a Pharmaceutical composition. These compounds inhibit the replication of influenza virusREFERIDA A UN DERIVADO DE PIRROLOPIRIDINA DE FORMULA (IA), DONDE Z1 ES F, Cl, CN, NO2, ENTRE OTROS Z2 ES R*, OR*, CO2R*, ENTRE OTROS Z3 ES H, OH, NH2, HALOGENO, ENTRE OTROS R1 ES H O ALQUILO C1-C6 R2 ES H, F, NH2, NH(ALQUILO C1-C4), ENTRE OTROS R3 ES H, Cl, F, OH, O(ALQUILO C1-C4), ENTRE OTROS R4 ES (a), (b) O (c) T ES UN CARBOCICLO NO AROMATICO C3-C10 OPCIONALMENTE SUSTITUIDO CON JA O UN HETEROCICLO NO AROMATICO DE 3 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON JB J ES
