HUTCHINSON, JOHN HOWARD,SEIDERS, THOMAS JON,WANG, BOWEI,ARRUDA, JEANNIE M.,ROPPE, JEFFREY ROGER,PARR, TIMOTHY
申请号：
ES10784122
公开号：
ES2445714T3
申请日:
2010.06.03
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the structure of the formula (I), or its pharmaceutically acceptable salt: ** Formula ** in which: R1 is -CO2H, -CO2RD, -CN, -C (>； = O) N (R9) 2, -C (>； = O) NHCH2CH2SO3H, or -C (>； = O) NHSO2R10, tetrazolyl, 5 or 5-oxo-2,5-dihydro- [1,2,4] oxadiazol-3-yl； RD is H or C1-C4 alkyl； R3 is H, C1-C4 alkyl, C3-C6 cycloalkyl, or C1-C4 fluoroalkyl； R4 is -NR7C (>； = O) OCH (R8) -CY； R7 is H or C1-C4 alkyl； R8 is H, C1-C4 alkyl, or C1-C4 fluoroalkyl； CY is a substituted or unsubstituted C3-C6 cycloalkyl or a substituted or unsubstituted phenyl, in which if CY is substituted, then CY is substituted with 1 or 2 RC； R9 is H, C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C6 cycloalkyl, or a substituted or unsubstituted phenyl； R10 is a C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C6 cycloalkyl, or a substituted or unsubstituted phenyl； each of RA, RB, and RC is independently selected from F, Cl, Br, I, -CN, -OH, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroalkoxy, C1-C4 alkoxy, and C1 heteroalkyl -C4； m is 0, 1, or 2； n is 1, 2, 3 or 4； p is 0, 1, or 2.Un compuesto que tiene la estructura de la fórmula (I), o su sal farmacéuticamente aceptable:**Fórmula** en la que: R1 es -CO2H, -CO2RD, -CN, -C(>；=O)N(R9)2, -C(>；=O)NHCH2CH2SO3H, o -C(>；=O)NHSO2R10, tetrazolilo, 5 o 5-oxo-2,5-dihidro-[1,2,4]oxadiazol-3-ilo； RD es H o alquilo C1-C4； R3 es H, alquilo C1-C4, cicloalquilo C3-C6, o fluoroalquilo C1-C4； R4 es -NR7C(>；=O)OCH(R8)-CY； R7 es H o alquilo C1-C4； R8 es H, alquilo C1-C4, o fluoroalquilo C1-C4； CY es un cicloalquilo C3-C6 sustituido o no sustituido o un fenilo sustituido o no sustituido, en el que si CY estásustituido, entonces CY está sustituido con 1 o 2 RC； R9 es H, alquilo C1-C6, fluoroalquilo C1-C6, cicloalquilo C3-C6, o un fenilo sustituido o no sustituido； R10 es un alquilo C1-C6, fluoroalquilo C1-C6, cicloalquilo C3-C6, o un fenilo sustituido o no sustituido； cada uno de RA, RB, y RC se selecciona independientemente de F, Cl, Br, I, -CN, -OH, alquilo C1-C4,
