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Bicyclic amides to improve glutamatergic synaptic responses
专利权人:
CORTEX PHARMACEUTICALS; INC.
发明人:
MUELLER, Rudolf,STREET, Leslie
申请号:
ES08795126
公开号:
ES2560095T3
申请日:
2008.08.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
An AMPA receptor enhancing compound according to formula A: ** Formula ** in which: W is oxygen X, Y and Z are independently selected from the group consisting of -N or -CR, in which : R is H, -Br, -Cl, -F, -CN, -NO2, -OR1, -SR1, -NR12, -C1-C6 branched or unbranched alkyl, which may be unsubstituted or substituted, in the that: R1 is H, -C1-C6 branched or unbranched alkyl, which may be unsubstituted or substituted, n is 0, 1, 2, 3, 4, 5 m is 0, 1, 2, 3, 4, 5 p is 1, 2, 3, 4, 5 R2 and R3 are each independently selected from H, a halogen, -CN, -NO2, -OR1, -SR1, -NR12, CF3, OH, C>; = O, a branched or unbranched C1-C6 alkyl, which may be unsubstituted or substituted, a branched or unbranched C2-C6 alkenyl, which may be unsubstituted or substituted, a branched or unbranched C2-C6 alkynyl, which may be unsubstituted or substituted, a C3-C7 -cycloalkyl which may be unsubstituted or substituted, an aryl that can be unsubstituted or substituted star, a heterocycle which may be unsubstituted or substituted, a carboxy alkyl which may be unsubstituted or substituted, a carboxyaryl which may be unsubstituted or substituted, a carboxyheteroaryl which may be unsubstituted or substituted, a sulfonylalkyl which may be unsubstituted or substituted, a sulfonaryl which may be unsubstituted or substituted or a sulfonylheteroaryl which may be unsubstituted or substituted, E and F are each independently selected from CH2m, CR2R3, A, CH2A, CR2>; = CR3 or are absent , with the proviso that E and F are not both absent; G is CR2R3, A, CH2A, CR2>; = CR3, CH2C>; = O, CH2CR2R3, or is absent, A is O, S, SO, SO2, C>; = O or CR2R3; or a pharmaceutically acceptable salt, solvate or polymorph thereof.Un compuesto mejorador de los receptores de AMPA de acuerdo con la fórmula A:**Fórmula** en la que: W es oxígeno X, Y y Z se seleccionan independientemente entre el grupo que consiste en -N o -CR, en la que: R es H, -Br, -Cl, -F, -CN, -NO2, -OR1, -SR1, -NR12, -alquilo C1-C6 ramificado o no-rami
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