RALL, WERNER,SOYKA, RAINER,KULINNA, CHRISTIAN,SCHNAUBELT, JUERGEN,SIEGER, PETER
申请号：
DK04765927
公开号：
DK1678165T3
申请日:
2004.10.12
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
