RAINER SOYKA,WERNER RALL,JUERGEN SCHNAUBELT,DR. PETER SIEGER,CHRISTIAN KULINNA
申请号：
MYPI 2010002645
公开号：
MY155425A
申请日:
2004.10.14
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE INVENTION RELATES TO AN IMPROVED PROCESS FOR PREPARING 4-[(3-CHLORO-4- FLUOROPHENYL)AMINO]-6-{[4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO}-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE AND RELATED AMINOCROTONYL COMPOUNDS AND THE PREPARATION OF A SUITABLE SALT OF 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-{[4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO}-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE FOR USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE.
