WERNER RALL,PETER SIEGER,RAINER SOYKA,CHRISTIAN KULINNA,JUERGEN SCHNAUBELT
申请号：
PT04765927
公开号：
PT1678165E
申请日:
2004.10.12
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
