THE INVENTION RELATES TO AN IMPROVED PROCESS FOR PREPARING 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-{[4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO}-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE AND RELATED AMINOCROTONYL COMPOUNDS AND THE PREPARATION OF A SUITABLE SALT OF 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-{[4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO}-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE FOR USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE.