JAESCHKE, Georg,LINDEMANN, Lothar,RICCI, Antonio,VIEIRA, Eric
申请号：
PH12017502128
公开号：
PH12017502128A1
申请日:
2017.11.22
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein R1 is hydrogen or F； n is 1 or 2 or to a pharmaceutically acceptable acid addition salt thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
